RIPK2-IN-7 [CAS 2789711-40-4]

RIPK2-IN-7 (Compound 10w) is an orally active, selective RIPK2 inhibitor (IC50: 0.6 nM) . RIPK2-IN-7 inhibits RIPK2 kinase activity, blocks the nucleotide-binding oligomerization domain (NOD) signaling pathway, and reduces the production of inflammatory factors (such as TNFα) . RIPK2-IN-7 can be used in the study of inflammatory bowel disease (IBD) [1].

[2789711-40-4]

C19H22FN5

339.41

NC1=C2C(C3=C(C=C(C=C3)C)F)=CN([C@H]4CC[C@H](CC4)N)C2=NC=N1

NOD-like Receptor (NLR) ; RIP kinase; TNF Receptor

RIPK2

Room temperature