Rivulariapeptolides 1185

Rivulariapeptolides 1185 is a high potent and selective serine protease inhibitor with IC50 values of 13.17 nM, 23.59 nM and 55.26 nM for chymotrypsin, elastase and proteinase K, respectively[1].

C61H87N9O15

1186.39

CCCC(N1[C@H](C(N[C@H](C(N[C@H](C(NC(C(N[C@H]2CC[C@@H](O)[N@@]3C2=O)=O)CC(C)C)=O)[C@@H](C)OC([C@H](C(C)C)NC([C@H](CC4=CC=C(O)C=C4)N(C([C@@H]3CC5=CC=CC=C5)=O)C)=O)=O)=O)[C@H](OC([C@@H]6CCCN6C(CCC)=O)=O)C)=O)CCC1)=O

Ser/Thr Protease

10 mM in DMSO

Room temperature