RJS308 (TFA)

RJS308 TFA is the PROTAC degrader for cyclosporin A (CypA) with a DC50 of 284 nM. RJS308 TFA exhibits antiviral activcity through inhibition of HIV-1 and HCV replication[1].

C65H76F3N13O13S

1336.44

C[C@@H](C1=CC=C(C2=C(C)N=CS2)C=C1)NC([C@H]3N(C[C@@H](C3)O)C([C@H](C(C)(C)C)NC(CCCCCN4N=NC(C[C@H]5C(N6N[C@@H](CCC6)C(O[C@H](C)C7=CC=C8C(C=C(C=C8)/C=C/CC(N[C@H](C(N5)=O)CC9=CC=C([N+]([O-])=O)C=C9)=O)=N7)=O)=O)=C4)=O)=O)=O.OC(C(F)(F)F)=O

Cyclophilin; HCV; HIV; PROTACs

99

4°C (Powder, sealed storage, away from moisture and light)

Room Temperature