RM-018 [CAS 2641993-55-5]

RM-018 is a potent, functionally distinct tricomplex KRASG12C active-state inhibitor. RM-018 retains the ability to bind and inhibit KRASG12C/Y96D and could overcome resistance. RM-018 binds specifically to the GTP-bound, active [“RAS (ON) ”] state of KRASG12C[1].

[2641993-55-5]

C56H72N8O8

985.22

O=C(N1CCC[C@@H](C(OCC(C)(C)CC2=[C@@]([C@@]3=C([C@H](C)OC)N=CC=C3)N(CC)C4=C2C=C5C=C4)=O)N1)[C@@H](NC([C@H](C(C)C)N(C)C([C@H]6CCN(C(C#CCN7CCOCC7)=O)C6)=O)=O)CC8=CC=CC5=C8

Ras

K-Ras

95.5

DMSO : 60 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature