RN277

RN277 is an inhibitor for LRRK2 type II kinase. RN277 can be used as a cellular tool targeting the LRRK2 inactive state. RN277 can inhibit LRRK1 kinase activity in vitro. RN277 inhibits LRRK2 kinase activity in vitro (IC50 = 70 nM) . RN277 reduces phosphorylation of Rab8a dose-dependently. RN277 can be studied in research for Parkingson’s disease[1].

C31H33ClN8O2

585.1

ClC1=NC(N2CCOCC2)=C(C(C3=CC=CC(NC(NC4=CC(C(C)(C)C)=NN4C5=CC=C(C)C=C5)=O)=C3)=CN6)C6=N1

LRRK2

Room temperature