Ro 31-7837 [CAS 120280-33-3]

APTO-253 (LOR-253) hydrochloride is a small molecule that inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 hydrochloride mediates anticancer activity via induction of Kruppel-like factor 4 (KLF4) tumor suppressor. APTO-253 hydrochloride exhibits antiarthritic activity.

[120280-33-3]

C17H16N2O2

280.32

N#CC1=CC=C2C(C(C3=[N+]([O-])C=CC=C3)CC(C)(C)O2)=C1

Apoptosis; c-Myc

Room temperature