RO5068760 [CAS 947182-25-4]

RO5068760 is a potent, orally active and selective non-ATP-competitive MEK1/2 inhibitor with an IC50 of 0.025 μM for MEK1. RO5068760 significantly inhibits MAPK pathway activity, thereby inducing G1 cell cycle arrest and apoptosis to inhibit cancer cell growth. RO5068760 exhibits significant efficacy in a broad spectrum of tumors with aberrant MAPK pathway activation. RO5068760 can be used for melanoma, colorectal cancer, non-small cell lung cancer (NSCLC), and pancreatic cancer research[1].

[947182-25-4]

C28H27FIN3O6

647.43

C[C@@H](C1=CC=CC=C1)[C@H](N2C([C@@H](C3=CC=C(C=C3)OC[C@H](O)CO)NC2=O)=O)C(NC4=C(C=C(C=C4)I)F)=O

Apoptosis; CDK; ERK; MEK; p38 MAPK; PARP

MEK1; MEK2

Room temperature