RO8191 [CAS 691868-88-9]

RO8191 (CDM-3008), an imidazonaphthyridine compound, is an orally active and potent interferon (IFN) receptor agonist. RO8191 directly binds to IFNα/β receptor 2 (IFNAR2) and activates IFN-stimulated genes (ISGs) expression and JAK/STAT phosphorylation. RO8191 shows antiviral activity against both HCV and EMCV with an IC50 of 200 nM for HCV replicon[1]. RO8191 is a cccDNA modulator (CDM) through interferon-like activity and has anti-HBV activity[2].

[691868-88-9]

C14H5F6N5O

373.21

FC(C1=C2C=CC3=NC(C4=NN=CO4)=CN3C2=NC(C(F)(F)F)=C1)(F)F

HBV; HCV; IFNAR; JAK; STAT

JAK1

99

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

-20°C (Powder, stored under nitrogen)

Blue Ice

H315, H319

H315, H319