ROCK2-IN-12 [CAS 3086603-12-2]

ROCK2-IN-12 (Compound A25) is a selective ROCK2 inhibitor with an IC50 of 7.0 nM for ROCK2 over ROCK1. ROCK2-IN-12 has potent antifibrotic effects via the TGF-β/Smad and ROCK2/STAT3 signaling pathways. ROCK2-IN-12 significantly reduces collagen deposition and reverses fibrotic progression in Bleomycin -induced pulmonary fibrosis (PF) mouse models. ROCK2-IN-12 can be used for lung diseases like pulmonary fibrosis research[1].

[3086603-12-2]

C23H18FN9O

455.45

FC(C=C1)=CC=C1CNCC2=NC(C3=CN=C4C=CC(NC5=CC6=C(C=C5)NN=C6)=NN43)=NO2

ROCK; STAT; TGF-beta/Smad

ROCK1; ROCK2; STAT3

Room temperature