Rotundine [CAS 483-14-7]

Rotundine is an antagonist of dopamine D1, D2 and D3 receptors with IC50s of 166 nM, 1.4 μM and 3.3 μM, respectively. Rotundine is also an antagonist of 5-HT1A with an IC50 of 370 nM.

[483-14-7]

C21H25NO4

355.43

COC1=CC=C2C(CN3CCC4=CC(OC)=C(OC)C=C4[C@]3([H])C2)=C1OC

5-HT Receptor; Dopamine Receptor

5-HT1 Receptor; D1 Receptor; D2 Receptor; D3 Receptor; mLAG-3

99.96

DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature

H302, H315, H319, H335

H302, H315, H319, H335