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Rp-dGTPαS [CAS 80902-29-0]
Rp-dGTPαS [CAS 80902-29-0]
SKU:QM-0063220
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Product Details
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Description
Rp-dGTPαS is the nucleotide substrate of SAMHD1 and is one of the enantiomers of the dNTPαS nucleotide. SAMHD1 is an essential regulator of cellular dNTPs that limits virus (HIV-1, etc.) replication in the CD4+ myeloid lineage and resting T cells. The SAMHD1 tetrameric complex catalyzes the hydrolysis of Rp-dGTPαS into 2'-deoxynucleosides and triphosphates[1].
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CAS Number
[80902-29-0]
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Molecular Formula
C10H16N5O12P3S
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Molecular Weight
523.25
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Smiles
OP(OP(O[P@@](OC[C@@H]1[C@@H](O)C[C@H](N(C=N2)C(NC(N)=N3)=C2C3=O)O1)(S)=O)(O)=O)(O)=O
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Target
HIV
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Rp-dGTPαS [CAS 80902-29-0]
Rp-dGTPαS is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.