RS-102221 [CAS 185376-97-0]

RS-102221 is a selective 5-HT2C receptor antagonist (Ki=10 nM) . RS-102221 shows nearly 100-fold selectivity for the 5-HT2C receptor as compared to the 5-HT2A and 5-HT2B receptors. RS-102221 can promote the differentiation of new nerve cells. RS-102221 increases food-intake and weight-gain in rats[1][2].

[185376-97-0]

C27H31F3N4O7S

612.62

O=S(C1=CC=C(C(F)(F)F)C=C1)(NC2=CC(C(CCCCN(CC3)CCC3(NC(N4)=O)C4=O)=O)=C(OC)C=C2OC)=O

5-HT Receptor

5-HT2 Receptor; α-1 microglobulin

10 mM in DMSO

Room temperature

H315-H319-H335

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501