RSK2/TOP2-IN-1

RSK2/TOP2-IN-1 is a RSK2/TOP2 dual inhibitor. RSK2/TOP2-IN-1 targets key tumor progression enzymes including ribosomal S6 kinase 2 and topoisomerases IIα/IIβ. RSK2/TOP2-IN-1 shows selectivity index > 2 against all squamous cell carcinoma (SCC) cell lines. RSK2/TOP2-IN-1 can induce cell apoptosis, autophagy and ROS production. RSK2/TOP2-IN-1 can be used for the research of cancer, such as squamous cell carcinoma[1].

C29H26O5S2

518.64

O=C(C1=CC=CC=C12)C(C(SC3=CC=C(OC)C=C3)C(SC4=CC=C(OC)C=C4)C(C)(C)O5)=C5C2=O

Apoptosis; Autophagy; Reactive Oxygen Species (ROS) ; Ribosomal S6 Kinase (RSK) ; Topoisomerase

RSK2; Topo II

Room temperature