RuOPt

RuOPt is a photoactivatable Ru (II) -Pt (IV) complex with reduced dark toxicity. Under irradiation, RuOPt induces apoptosis, generates ROS, and inhibits tumor spheroid growth, demonstrating comparable phototoxicity[1].

C54H56N8O13PtRu

1321.22

O=C1O[Pt]2(OC1=O)(OCCCOC(CCCC3=CC=[N]([Ru+2]456([N]7=CC=CC=C7C8=[N]6C=CC=C8)[N](C=CC=C9)=C9C%10=CC=CC=[N]%105)C(C%11=[N]4C=CC=C%11)=C3)=O)(OC(C%12=CC=CC=C%12)=O)[NH2][C@@H]%13CCCC[C@H]%13[NH2]2.O=C[O-].O=C[O-]

Apoptosis; Photosensitizer; Reactive Oxygen Species (ROS)

Room temperature