S-1255 [CAS 203918-14-3]

S-1255 is an orally active and highly selective endothelin ETA receptor antagonist (Kd=0.39 nM) . S-1255 blocks vasoconstriction and sustains hypotensive effects in hypertensive rats. S-1255 is promising for research of hypertension and cardiovascular disorders[1].

[203918-14-3]

C27H24O7

460.48

OC(C1=C(C2=CC=C(C=C2)OC)C3=CC(OC(C)C)=CC=C3O[C@@H]1C4=CC=C(OCO5)C5=C4)=O

Endothelin Receptor

ETA

Room temperature