S-18326 [CAS 167843-21-2]

S-18326 is an orally active direct thrombin inhibitor. S-18326 inhibits thrombus formation by reversibly and with high affinity binding to the active site of thrombin, directly preventing the conversion of fibrinogen to fibrin. S-18326 effectively prolongs various clotting times in human plasma. S-18326 has demonstrated antithrombotic efficacy in multiple animal models without causing thrombocytopenia. S-18326 can be used in research on thromboembolic diseases[1].

[167843-21-2]

C23H37BN6O5

488.39

O=C(N(C1CCCC1)CC(N[C@@H](CCCNC(N)=N)B(O)O)=O)[C@H](NC(C)=O)CC2=CC=CC=C2

Thrombin

Room temperature

H302-H315-H319-H335

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501