S-8666 [CAS 103968-87-2]

S-8666 is an orally active uricosuric antihypertensive diuretic. The S-8666 has both S- (-) - and R- (+) -isomers. The diuretic and sodium-excretion activities of it are entirely dominated by the S- (-) -isomer, while the R- (+) -isomer shows no significant activity. S-8666 relies on the organic acid transport system to be secreted through the proximal tubule. S-8666 exhibits a clear uric acid excretion-promoting activity and diuretic effect in various species (such as rats and chimpanzees) [1][2].

[103968-87-2]

C11H11Cl2NO5S

340.18

O=C(C1OC2=C(C1)C=C(S(=O)(N(C)C)=O)C(Cl)=C2Cl)O

Endogenous Metabolite

Room temperature