(S) -ACE-OH is a molecular glue with anticancer activity. (S) -ACE-OH promotes nucleoporin degradation and disruption of nucleocytoplasmic trafficking by inducing the interaction between E3 ubiquitin ligase TRIM21 and nucleoporin NUP98[1].
Molecular Formula
C19H24N2OS
Molecular Weight
328.47
Smiles
C[C@@H](C1=CC2=C(SC3=C(N2CCCN(C)C)C=CC=C3)C=C1)O
Target
Molecular Glues
Purity
99.17
Solubility
DMSO : 100 mg/mL (ultrasonic)
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)