(S) -BI 665915 [CAS 1360550-05-5]

(S) -BI 665915 is an orally active oxadiazole-containing 5-lipoxygenase-activating protein (FLAP) inhibitor with an IC50 of 1.7 nM for FLAP binding. (S) -BI 665915 inhibits FLAP functional in human whole blood with an IC50 of 45 nM. (S) -BI 665915 demonstrates an excellent cross-species agent metabolism and pharmacokinetics (DMPK) profile and a dose-dependent inhibition of LTB4 production[1].

[1360550-05-5]

C24H26N8O2

458.52

O=C(N(C)C)CN1N=CC(C2=NC([C@@](C3CC3)(C4=CC=C(C5=CN=C(N)N=C5)C=C4)C)=NO2)=C1

FLAP

10 mM in DMSO

Room temperature