(S) -Deoxy-thalidomide [CAS 107657-57-8]

(S) -Deoxy-thalidomide is an E3 ubiquitin ligase ligand. (S) -Deoxy-thalidomide can be linked to the target protein ligand through a linker to form PROTAC K-Ras Degrader-3. PROTAC K-Ras Degrader-3 can target KRAS mutant proteins for degradation[1].

[107657-57-8]

C13H12N2O3

244.25

O=C(CC1)NC([C@H]1N2C(C3=CC=CC=C3C2)=O)=O

Ligands for E3 Ligase

Cereblon

Room temperature