(S) -Lercanidipine [CAS 185197-71-1]

(S) -Lercanidipine is a calcium channel blocker with antihypertensive and neuroprotective activities. (S) -Lercanidipine reduces oxidative stress and protects auditory sensory hair cells from noise-induced damage. (S) -Lercanidipine showed significant protective effects on cell viability in in vitro experiments, especially at low concentrations. (S) -Lercanidipine has been found to effectively reduce the hearing threshold of mice after noise stimulation and protect the survival of outer hair cells. The antioxidant properties of (S) -Lercanidipine are reflected in its increased expression of antioxidant enzyme genes and decreased expression of oxidative enzyme genes. (S) -Lercanidipine administration is effective in reducing noise-induced hearing loss both before and after noise exposure. (S) -Lercanidipine may alleviate noise-induced hearing loss and protect the survival of outer hair cells through its antioxidant mechanism[1].

[185197-71-1]

C36H41N3O6

611.73

O=C(OC(C)(CN(C)CCC(C1=CC=CC=C1)C2=CC=CC=C2)C)C3=C(NC(C)=C([C@@H]3C4=CC=CC([N+]([O-])=O)=C4)C(OC)=O)C

Calcium Channel; Sodium Channel

Room temperature