(S) -MDL-101146 [CAS 163660-59-1]

(S) -MDL-101146 is the S-isomer of MDL-101146. MDL-101146 is an orally active, competitive and reversible inhibitor against human neutrophil elastase (HNE) with a Ki value of 25 nM. MDL-101146 inhibits HNE-induced hemorrhage in hamsters. MDL-101146 is promising for research of emphysema, rheumatoid arthritis, chronic bronchitis, cystic fibrosis, adult respiratory distress syndrome and glomerulonephritis[1].

[163660-59-1]

C29H37F5N4O6

632.62

O=C(NC([C@H](C(C)C)NC(C1=CC=C(C(N2CCOCC2)=O)C=C1)=O)=O)[C@H]3N([C@@H](C(C)C)C(C(F)(F)C(F)(F)F)=O)CCC3

Elastase

Room temperature