(S, R) -CFT8634 [CAS 2704617-95-6]

(S, R) -CFT8634 (compound 176) is a selective and orally active PROTAC-class BRD9 protein degrader. (S, R) -CFT8634 has the potential to study BRD9-mediated diseases, including but not limited to abnormal cell proliferation. (S, R) -CFT8634 consists of a target protein ligand (red part) BRD9 ligand-5 , an E3 ligase ligand (blue part) CRBN ligand-11 (HY-169989), and a PROTAC linker (black part) 1- (3,3-Difluoro-4-piperidinyl) piperazine (HY-169991). E3 ligase ligand and linker can form E3 Ligase Ligand-linker Conjugate 142 (HY-169990).

[2704617-95-6]

C37H45F3N6O5

710.79

CC(C(C1=CC(OC)=C(C(OC)=C1)CN2CC(F)([C@@H](N3CCN(C4=C(C=C(C=C4)N[C@H]5C(NC(CC5)=O)=O)F)CC3)CC2)F)=CN6C)=C(C)C6=O

Epigenetic Reader Domain; PROTACs

10 mM in DMSO

Room temperature