(S, R) -GSK321 [CAS 1816272-18-0]
(S, R) -GSK321 [CAS 1816272-18-0]
SKU:QM-0142685-01
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Product Details
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Description
(S, R) -GSK321 is the (S, R) -enantiomer of GSK321. GSK321 is a potent, selective mutant IDH1 inhibitor with IC50 values of 2.9, 3.8, 4.6 and 46 nM for R132G, R132C, R132H and WT IDH1, respectively, and >100-fold selectivity over IDH2. GSK321 induces decrease in intracellular 2-HG, abrogation of the myeloid differentiation block and induction of granulocytic differentiation at the level of leukemic blasts and more immature stem-like cells. GSK321can be used for research of acute myeloid leukemia (AML) and other cancers[1].
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CAS Number
[1816272-18-0]
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Molecular Formula
C28H28FN5O3
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Molecular Weight
501.55
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Smiles
C[C@@H](O)C1=CC=CC(NC(C2=NN(C3=C2CN(C[C@@H]3C)C(C4=CC=CN4)=O)CC5=CC=C(C=C5)F)=O)=C1
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Target
Isocitrate Dehydrogenase (IDH)
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Isoform
IDH1
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Purity
98.62
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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(S, R) -GSK321 [CAS 1816272-18-0]
(S, R) -GSK321 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.