(S, R, S) -AHPC-Boc derivative 1 [CAS 2086298-33-9]
(S, R, S) -AHPC-Boc derivative 1 [CAS 2086298-33-9]
SKU:QM-0011214-01
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Product Details
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Description
(S, R, S) -AHPC-Boc derivative 1 (Compound 80-9; VH032-Boc derivative 1) is a selective proteasomal degrader targeting MALT1, which recruits the E3 ubiquitin ligase CRBN to form a ternary complex with MALT1, leading to ubiquitination and subsequent proteasomal degradation of MALT1. (S, R, S) -AHPC-Boc derivative 1 inhibits the NF-κB signaling pathway by disrupting the CBM complex, demonstrating potential for inducing apoptosis in ABC-DLBCL cells. (S, R, S) -AHPC-Boc derivative 1 is promising for research of MALT1-dependent cancers, such as diffuse large B-cell lymphoma (DLBCL) [1].
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CAS Number
[2086298-33-9]
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Molecular Formula
C28H40N4O6S
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Molecular Weight
560.71
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Smiles
CC(C)(C)OC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)CO)=O)=O)=O
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Target
MALT1
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Purity
98.56
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Storage Conditions
-20°C, 3 years (Powder)
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Shipping Conditions
Blue Ice
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(S, R, S) -AHPC-Boc derivative 1 [CAS 2086298-33-9]
(S, R, S) -AHPC-Boc derivative 1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.