(S, R, S) -AHPC-C5-COOH [CAS 2267282-19-7]

(S, R, S) -AHPC-C5-COOH (VH032-C5-COOH) is a synthesized E3 ligase ligand-linker conjugate, contains the VH032 VHL-based ligand and a linker to form PROTACs. VH-032 is a selective and potent inhibitor of VHL/HIF-1α interaction with a Kd of 185 nM, has the potential for the study of anemia and ischemic diseases[1].

[2267282-19-7]

C29H42N4O5S

558.73

O=C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)[C@H](C(C)(C)C)NCCCCCCC(O)=O

E3 Ligase Ligand-Linker Conjugates; HIF/HIF Prolyl-Hydroxylase

Von Hippel-Lindau (VHL)

98.81

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature

H302, H315, H319, H335

H302, H315, H319, H335