(S, R, S) -AHPC-C5-NH2 [CAS 2170695-19-7]

(S, R, S) -AHPC-C5-NH2 (VH032-C5-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for estrogen-related receptor α (ERRα) PROTAC degrader[1].

[2170695-19-7]

C28H41N5O4S

543.72

O=C([C@H]1N(C([C@@H](NC(CCCCCN)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2

E3 Ligase Ligand-Linker Conjugates

Von Hippel-Lindau (VHL)

10 mM in DMSO

Room temperature

H302-H315-H319-H335

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501