(S, R, S) -AHPC-C6-PEG3-C4-Cl [CAS 1835705-55-9]

(S, R, S) -AHPC-C6-PEG3-C4-Cl (VH032-C6-PEG3-C4-Cl) is a conjugate of ligands for E3 and 20-atom-length linker. The connector of linker is Halogen group. (S, R, S) -AHPC-C6-PEG3-C4-Cl incorporates the (S, R, S) -AHPC based VHL ligand and an alkyl/ether-based linker. (S, R, S) -AHPC-C6-PEG3-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].

[1835705-55-9]

C38H59ClN4O7S

751.42

O=C([C@H]1N(C([C@H](C(C)(C)C)NC(CCCCCOCCOCCOCCCCCCCl)=O)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2

E3 Ligase Ligand-Linker Conjugates

Von Hippel-Lindau (VHL)

97.01

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature

H302, H315, H319, H335

H302, H315, H319, H335