(S, R, S) -AHPC-C8-NH2 [CAS 2341796-79-8]

(S, R, S) -AHPC-C8-NH2 (VH032-C8-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used for AKT PROTAC degrader. (S, R, S) -AHPC-C8-NH2 is XF038-164A, example 8, extracted from patent WO2019173516A1[1].

[2341796-79-8]

C31H47N5O4S

585.8

O=C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)[C@H](C(C)(C)C)NC(CCCCCCCCN)=O

E3 Ligase Ligand-Linker Conjugates

Von Hippel-Lindau (VHL)

97.04

DMSO : ≥ 100 mg/mL

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature

H302, H315, H319, H335

H302, H315, H319, H335