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(S, R, S) -AHPC-Me [CAS 1948273-02-6]

(S, R, S) -AHPC-Me [CAS 1948273-02-6]

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QM-0137326-01

£67.44 GBP
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Product Details

  • Description

    (S, R, S) -AHPC-Me (VHL ligand 2) is the (S, R, S) -AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S, R, S) -AHPC-Me can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 [2].

  • CAS Number

    [1948273-02-6]

  • Molecular Formula

    C23H32N4O3S

  • Molecular Weight

    444.6

  • Smiles

    N[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O

  • Target

    Ligands for E3 Ligase

  • Isoform

    Von Hippel-Lindau (VHL)

  • Purity

    99.96

  • Solubility

    DMSO : 100 mg/mL (ultrasonic)

  • Storage Conditions

    -20°C, 3 years; 4°C, 2 years (Powder)

  • Shipping Conditions

    Room Temperature

  • Hazard Statement

    H302, H315, H319, H335

  • Precautions

    H302, H315, H319, H335
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Variant Variant total Quantity Price Variant total
25 mgQM-0137326-01
25 mgQM-0137326-01
£67.44/ea		 £0.00
£67.44/ea £0.00
50 mgQM-0137326-02
50 mgQM-0137326-02
£94.75/ea		 £0.00
£94.75/ea £0.00
100 mgQM-0137326-03
100 mgQM-0137326-03
£118.38/ea		 £0.00
£118.38/ea £0.00
500 mgQM-0137326-04
500 mgQM-0137326-04
£301.50/ea		 £0.00
£301.50/ea £0.00
1 gQM-0137326-05
1 gQM-0137326-05
£426.65/ea		 £0.00
£426.65/ea £0.00
5 gQM-0137326-06
5 gQM-0137326-06
£953.96/ea		 £0.00
£953.96/ea £0.00
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(S, R, S) -AHPC-Me [CAS 1948273-02-6]

(S, R, S) -AHPC-Me is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.