(S, R, S) -AHPC-PEG2-N3 [CAS 2010159-45-0]

(S, R, S) -AHPC-PEG2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S, R, S) -AHPC based VHL ligand and 2-unit PEG linker used in PROTAC technology. (S, R, S) -AHPC-PEG2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

[2010159-45-0]

C28H39N7O6S

601.72

O=C(N[C@@H](C(C)(C)C)C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)=O)COCCOCCN=[N+]=[N-]

E3 Ligase Ligand-Linker Conjugates

Von Hippel-Lindau (VHL)

99.94

DMSO : 125 mg/mL (ultrasonic) |Ethanol : 50 mg/mL (ultrasonic)

-20°C (Powder, stored under nitrogen)

Blue Ice

H302, H315, H319, H335

H302, H315, H319, H335