(S, R, S) -AHPC-PEG3-N3 [CAS 1797406-80-4]

(S, R, S) -AHPC-PEG3-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S, R, S) -AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. (S, R, S) -AHPC-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

[1797406-80-4]

C30H43N7O7S

645.77

O=C(N[C@@H](C(C)(C)C)C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)=O)COCCOCCOCCN=[N+]=[N-]

E3 Ligase Ligand-Linker Conjugates

Von Hippel-Lindau (VHL)

99.67

DMSO : 50 mg/mL (ultrasonic) |Ethanol : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature

H302, H315, H319, H335

H302, H315, H319, H335