(S) -Ro 32-0432 [CAS 1781828-85-0]

(S) -Ro 32-0432 is a potent, selective, ATP-competitive and orally active PKC inhibitor. The IC50 values of (S) -Ro 32-0432 for PKCα, PKCβI, PKCβII, PKCγ and PKCε are 9.3 nM, 28 nM, 30 nM, 36.5 nM and 108.3 nM, respectively. (S) -Ro 32-0432 is also a selective G protein-coupled receptor kinase 5 (GRK5) inhibitor. (S) -Ro 32-0432 prevents T-cell activation and has the potential for chronic inflammatory and autoimmune diseases research[1][2].

[1781828-85-0]

C28H29ClN4O2

489.01

O=C(C(C1=C(C[C@@H](CN(C)C)CC2)N2C3=C1C=CC=C3)=C4C5=CN(C)C6=C5C=CC=C6)NC4=O.[H]Cl

PKC

PKCα; PKCβ; PKCγ; PKCε

10 mM in DMSO

Room temperature