(S) -TCO-PEG3-maleimide

(S) -TCO-PEG3-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. (S) -TCO-PEG3-maleimide is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

C24H37N3O8

495.57

O=C(O[C@H]1CCC/C([H])=C/CC1)NCCOCCOCCOCCNC(CCN2C(C=CC2=O)=O)=O

PROTAC Linkers

PEG Linkers

10 mM in DMSO

Room temperature

H302-H315-H319-H335

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501