(S) -VU0637120 [CAS 1175940-86-9]

(S) -VU0637120 is a Y4R antagonist that effectively reduces the binding response of its endogenous ligand, pancreatic polypeptide (PP), on Y4R, with an IC50 value of 2.7 μM. (S) -VU0637120 binds to the allosteric site of Y4R, which is located in the core region of the Y4R transmembrane structure, near the binding pocket of pancreatic polypeptide (PP), with a KB value of 300-400 nM. (S) -VU0637120 holds potential for research in the field of metabolic diseases[1].

[1175940-86-9]

C16H19N3O5S2

397.47

O=C([C@H]1N(CCCC1)S(C)(=O)=O)NC2=NC3=CC(OCCO4)=C4C=C3S2

Neuropeptide Y Receptor

NPY Y4 receptor

99.5

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