S-WJM992

S-WJM992 (compound 10ahb) is an antiparasitic agent that inhibits ATPase activity under high [Na+] conditions. S-WJM992 also has significant inhibitory effects on parasites that have developed PfATP4 inhibitor-resistance. S-WJM992 is a potential transmission blocker that effectively inhibits gamete development and prevents parasite transmission to mosquitoes via blood feeding[1].

C22H18ClFN6O3

468.87

O=C([C@](N1C)(CCC2=O)N2C3=C(C(F)=CC(C4=CN(C)N=C4)=C3)C1=O)NC5=CC(Cl)=CN=C5

Na+/K+ ATPase; Parasite

Room temperature