SAICAR [CAS 3031-95-6]

SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner, with an EC50 of 0.3 mM. SAICAR stimulates PKM2 and promotes cancer cell survival in glucose-limited conditions[1][2].

[3031-95-6]

C13H19N4O12P

454.28

O=C(O)C[C@@H](C(O)=O)NC(C1=C(N)N([C@H]2[C@@H]([C@@H]([C@@H](COP(O)(O)=O)O2)O)O)C=N1)=O

Endogenous Metabolite

Human Endogenous Metabolite

99.57

DMSO : 220 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

4°C (Powder, sealed storage, away from moisture and light)

Room Temperature