Salicylate (choline) [CAS 2016-36-6]
Salicylate (choline) [CAS 2016-36-6]
SKU:QM-0051608
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Product Details
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Description
Salicylate choline is an orally active derivative of Aspirin (acetylsalicylic acid). Salicylate choline significantly reduces IL-1β, IL-6, TNF-α and IL-10 levels in cells. Salicylate choline enhances the anti-tumor activity of the CRM1 inhibitor Selinexor (KPT-330) (HY-17536) through inducing S-phase cell cycle arrest and impairing DNA damage repair. Salicylate choline combined with Selinexor demonstrates excellent anti-tumor efficacy in mice xenograft model harboring JeKo-1 cells. Salicylate choline can be used for the study of rheumatic diseases, inflammation and cancer[1][2][3][4].
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CAS Number
[2016-36-6]
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Molecular Formula
C12H19NO4
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Molecular Weight
241.28
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Smiles
O=C(O)C1=CC=CC=C1[O-].C[N+](C)(CCO)C
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Target
Drug Derivative; Interleukin Related; Polo-like Kinase (PLK) ; TNF Receptor
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Shipping Conditions
Room temperature
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Hazard Statement
H302-H315-H319-H335
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Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Salicylate (choline) [CAS 2016-36-6]
Salicylate (choline) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.