SAR441255 (TFA)

SAR441255 TFA is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. SAR441255 TFA displays high potency with balanced activation of all three target receptors. SAR441255 TFA shows positive acute glucoregulatory effectss in diabetic obese monkeys[1].

C225H355N57O63.xC2HF3O2

O=C(O)[C@H](CCC(N[C@H](C(O)=O)CCC(NCCCC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NC(C)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C(NCC(N1[C@H](C(N2[C@H](C(N[C@H](C(NC(C)(C(N[C@H](C(N3[C@H](C(N4[C@H](C(N5[C@H](C(N[C@H](C(N)=O)CCCCN)=O)CCC5)=O)CCC4)=O)CCC3)=O)CCCCN)=O)C)=O)CO)=O)CCC2)=O)CCC1)=O)=O)C)=O)C)=O)CCCCN)=O)CC(C)C)=O)CC6=CNC7=CC=CC=C67)=O)CCC(O)=O)=O)[C@H](CC)C)=O)CC8=CC=CC=C8)=O)CCC(O)=O)=O)C)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CO)NC([C@H]([C@@H](C)O)NC([C@H](CC9=CC=CC=C9)NC([C@H]([C@@H](C)O)NC(CNC([C@H](CC%10=CNC=N%10)NC(C(C)(C)NC([C@@H](N)CC%11=CNC=N%11)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC(CCCCCCCCCCCCCCC)=O.OC(C(F)(F)F)=O.[x]

GCGR; GLP Receptor

99.93

DMSO : 66.67 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

Blue Ice