SARS-CoV-2-IN-11 [CAS 2722635-28-9]

SARS-CoV-2-IN-11 is a potent and nontoxic inhibitor of SARS-CoV-2 3CL protease (3CLpro) with an IC50 and EC50 of 0.17 and 1.45 nM, respectively. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals[1].

[2722635-28-9]

C27H38F2N3NaO8S

625.66

O=C(NCC1)[C@@H]1C[C@@H](C(O)S(=O)(O[Na])=O)NC([C@H](CC(C)C)NC(OC(C2=CC=CC=C2)C3CCC(F)(CC3)F)=O)=O

SARS-CoV

10 mM in DMSO

Room temperature