SB-1295

SB-1295 is an orally active CDK9/T1 inhibitor (IC50=0.17 μM) . SB-1295 shows antiproliferative activity in HCT 116 and MIA PaCa-2 cells. SB-1295 also induces MIA PaCa-2 cell death by inducing intracellular ROS production, reducing mitochondrial membrane potential and inducing apoptosis. SB-1295 has the potential to study cancer[1].

C23H22ClNO6

443.88

OC1=C2C(OC(/C=C/C3=CC=CC=C3Cl)=CC2=O)=C([C@]4([H])[C@H](O)C[N+](C)([O-])CC4)C(O)=C1

Apoptosis; CDK; Reactive Oxygen Species (ROS)

10 mM in DMSO

Room temperature