SB 203580 sulfone [CAS 152121-46-5]

SB 203580 sulfone is an analog of p38 MAP kinase inhibitor SB 203580. SB 203580 sulfone inhibits the IL-1 production (IC50 of 0.2 μM in monocytes) and binds competitively with CSAID binding proteins (CSBP), inhibits it mediated stress response signaling with an IC50 of 0.03 μM. SB 203580 sulfone inhibits 5-LO with an IC50 value of 24 µM. SB 203580 sulfone can be used in the research of inflammatory diseases[1][2].

[152121-46-5]

C21H16FN3O2S

393.43

O=S(C1=CC=C(C2=NC(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)N2)C=C1)(C)=O

Drug Derivative; Interleukin Related; Lipoxygenase

IL-1

99.25

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 50 mg/mL (ultrasonic; warming)

-20°C, 3 years (Powder)

Blue Ice