SB 247083 [CAS 188186-61-0]

SB 247083 is a selective, competitive and orally active endothelin-A receptor antagonist with a Ki of 0.41 nM. SB 247083 shows a Ki of 467 nM to endothelin-B receptor. SB 247083 shows a Kb of 3.5 nM for ET-1-induced contraction of rat aorta. SB 247083 can be used for the research of cardiovascular disease[1].

[188186-61-0]

C34H33ClN2O7

617.09

COC(C=C1C(OCC1)=C2)=C2C/C(C(O)=O)=C\C3=C(C4=C(C=C(C=C4)Cl)OCC5=C(C=CC=C5)C(O)=O)N(N=C3)CCCC

Endothelin Receptor

ETA; ETB

Room temperature