SB-T-1214 [CAS 178250-23-2]

SB-T-1214 (SBT) is a taxane. SB-T-1214 efficiently inhibits expression of stem cell-related genes (Oct4, Sox2, and c-Myc) and induces apoptosis of colon cancer spheroids with drug resistant tumorigenic CD133+/CD44+ cells. SB-T-1214 strongly represses tumor growth in Pgp+ DLD-1 human colon tumor xenografts mice model. SB-T-1214 can be used for antitumor research, especially against tumors with drug resistance, such as colon, pancreatic and renal cancers[1][2].

[178250-23-2]

C45H59NO15

853.95

CC(O[C@]12[C@@]3([H])[C@@H]([C@]4(C(C)(C([C@H](C([C@@]3([C@H](C[C@@]1([H])OC2)O)C)=O)OC(C5CC5)=O)=C([C@H](C4)OC([C@H](O)[C@H](/C=C(C)\C)NC(OC(C)(C)C)=O)=O)C)C)O)OC(C6=CC=CC=C6)=O)=O

Apoptosis; c-Myc; Oct3/4

Room temperature