SBI-0087702 promots the cytoplasmic localization of ATF2 in melanoma cells. SBI-0087702-induced translocation of ATF2 to the mitochondria results in increased apoptosis due to loss of mitochondrial membrane integrity. SBI-0087702 also inhibits growth and motility of melanoma cells. SBI-0087702 was shown to inhibit ATF2 phosphorylation on Thr52 by PKCε[1].
CAS Number
[864431-36-7]
Molecular Formula
C21H23NO2
Molecular Weight
321.41
Smiles
COC1=CC=C(CCNCC2=C3C=CC=CC3=C(OC)C=C2)C=C1
Target
PKC
Purity
99.55
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)