SBI-0640726 [CAS 1321827-45-5]

SBI-0640726 is an eIF4G1 inhibitor with antiproliferative activity in melanoma. SBI-0640726 disrupts the eIF4F translation initiation complex by inhibiting AKT and NF-kB signaling pathways. SBI-0640726 inhibits the growth of NRAS and BRAF mutant melanoma in vitro[1].

[1321827-45-5]

C23H15ClN2O2

386.83

O=C(C1=C(C2=CC=CC=C2)C3=C(C=CC(Cl)=C3)NC1=O)/C=C/C4=CC=CC=N4

Akt; Eukaryotic Initiation Factor (eIF) ; NF-κB

Room temperature