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SC144 [CAS 895158-95-9]

SC144 [CAS 895158-95-9]

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QM-0151898-01

£78.82 GBP
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Product Details

  • Description

    SC144 is a first-in-class, orally active gp130 (IL6-beta) inhibitor. SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. SC144 shows potent inhibition of gp130 ligand-triggered signaling. SC144 induces apoptosis in human ovarian cancer cells[1].

  • CAS Number

    [895158-95-9]

  • Molecular Formula

    C16H11FN6O

  • Molecular Weight

    322.3

  • Smiles

    O=C(C1=NC=CN=C1)NNC2=NC3=C(N4C2=CC=C4)C=CC(F)=C3

  • Target

    Apoptosis; Interleukin Related

  • Isoform

    IL-6

  • Purity

    99.48

  • Solubility

    DMSO : 16.67 mg/mL (ultrasonic)

  • Storage Conditions

    -20°C, 3 years; 4°C, 2 years (Powder)

  • Shipping Conditions

    Room Temperature

  • Hazard Statement

    H302, H315, H319, H335

  • Precautions

    H302, H315, H319, H335
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Variant Variant total Quantity Price Variant total
5 mgQM-0151898-01
5 mgQM-0151898-01
£78.82/ea		 £0.00
£78.82/ea £0.00
10 mM - 1 mLQM-0151898-02
10 mM - 1 mLQM-0151898-02
£89.13/ea		 £0.00
£89.13/ea £0.00
10 mgQM-0151898-03
10 mgQM-0151898-03
£124.00/ea		 £0.00
£124.00/ea £0.00
25 mgQM-0151898-04
25 mgQM-0151898-04
£263.84/ea		 £0.00
£263.84/ea £0.00
50 mgQM-0151898-05
50 mgQM-0151898-05
£407.21/ea		 £0.00
£407.21/ea £0.00
100 mgQM-0151898-06
100 mgQM-0151898-06
£658.72/ea		 £0.00
£658.72/ea £0.00
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SC144 [CAS 895158-95-9]

SC144 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.