SCH-23390 (maleate) [CAS 87134-87-0]

SCH-23390 maleate (R- (+) -SCH-23390 maleate) is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively. SCH-23390 maleate is a potent and high efficacy human 5-HT2C receptor agonist with a Ki of 9.3 nM. SCH-23390 maleate also binds with high affinity to the 5-HT2 and 5-HT1C receptors. SCH-23390 maleate inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC50 of 268 nM[1][2][3].

[87134-87-0]

C21H22ClNO5

403.86

OC1=C(Cl)C=C2CCN(C)C[C@H](C3=CC=CC=C3)C2=C1.O=C(O)/C=C\C(O)=O

5-HT Receptor; Dopamine Receptor; Potassium Channel

5-HT1 Receptor;5-HT2 Receptor; D1 Receptor; D5 Receptor; α-1 microglobulin

10 mM in DMSO

Room temperature