SCR130 [CAS 2377858-38-1]

SCR130 is a SCR7-based DNA nonhomologous end-joining (NHEJ) inhibitor. SCR130 inhibits the end-joining of DNA in a Ligase IV-dependent manner. SCR130 is specific to Ligase IV, and shows minimal or no effect on Ligase III and Ligase I mediated joining. SCR130 induces cell apoptosis and has anticancer activity[1].

[2377858-38-1]

C19H13Cl2N3O2S

418.3

O=C1NC(NC(C12N=C(CC2C3=CC=C(C=C3)Cl)C4=CC=C(Cl)C=C4)=O)=S

Apoptosis; DNA/RNA Synthesis

98.23

DMSO : 100 mg/mL (ultrasonic; warming)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature