SCR1693 [CAS 1442559-20-7]

SCR1693 is a selective, reversible, orally active and noncompetitive inhibitor of AChE (IC50 = 0.68 μM) as well as a calcium channel blocker. SCR1693 reduces tau phosphorylation levels, and inhibits the generation and release of Aβ. SCR1693 restores insulin signaling and improves cognitive deficits. SCR1693 can be used for the study of Alzheimer's disease, especially which complicated with type 2 diabetes mellitus[1][2][3].

[1442559-20-7]

C24H28ClN3O2

425.95

O=C(C1=C(C)N=C2NC3=C(CC(C)(CC3)C)C(N)=C2C1C4=C(Cl)C=CC=C4)OCC

Akt; Amyloid-β; Calcium Channel; Cholinesterase (ChE) ; GSK-3; Phosphatase; PKA; Tau Protein

AChE

Room temperature